Little Manhattan: Hilarious, clever, insightful and adorable take on a boy's life in NYC and his first love.
Enchanted: A failed attempt at snarky parody of Disney princess movies.
I am Legend: NYC would be a really scary city if it were overrun with vampire-like mutants ... then again, ANY city would be scary if it were overrun with vampire-like mutants; fortunately, Will Smith is kicking A and not taking names (except of his sweet dog).
Cloverfield: Blair Witch Project meets Godzilla meets Outbreak and JJ Abrams totally pulls it off.
Sleepless in Seattle: The Empire State Building with a big heart on it; need I say more? (okay, so I haven't seen it lately, but it just popped into my mind ... I'm not going to get into ALL the movies I've seen set in NYC, because that would take forever.)